Tyrosinase is an important marker of melanoma and is closely related to diseases such as albinism and Parkinson's disease. Therefore, the development of optical sensing and imaging analysis methods for tyrosinase is of great significance for the diagnosis of related diseases. The traditional detection tyrosinase fluorescent probes all contain 4-hydroxybenzene units, which are interfered by reactive oxygen species during imaging analysis of biological systems such as cells, thereby seriously affecting the accuracy of the detection results. Recently, with the strong support of the National Natural Science Foundation of China, the Ministry of Science and Technology, and the Chinese Academy of Sciences, the research team proposed a new tyrosinase recognition unit (3-hydroxybenzyl), which was combined with a stable semi-paritrin. The near-infrared optical probe (pictured) suitable for imaging cells and live zebrafish effectively solves the problem of interference of existing fluorescent probes by reactive oxygen species. Related results published in "German Applied Chemistry" (Angew.
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The optical probe with excellent performance is the material basis for constructing optical sensing and living imaging analysis methods with high sensitivity and high spatial-temporal resolution, and its development has been receiving attention. The Ma Huimin Research Group of the Laboratory of Analytical Chemistry of the Institute of Chemistry, Chinese Academy of Sciences has been engaged in research in this area for a long time and has achieved a series of results.
(Angew. Chem. Int. Ed., 2012, 51, 6432; Anal. Chem., 2014, 86, 6115; Angew.
Chem. Int. Ed., 2014, 53, 10916; Chem. Sci., 2016, 7, 788; Chem. Sci., 2016, 7,
4694). In recent years, the group has also been invited to systematically summarize and review various design methods for optical probes (Chem. Rev., 2014, 114, 590-659; Chem. Sci.,
2016, 7, 6309-6315).
Chem. Int. Ed. 2016, 55, 14728-14732).